TY  - CONF
T1  - Matching Spatial Regions with Combinations of Interacting Gene Expression Patterns
T2  - Communications in Computer and Information Science
Y1  - 2008
A1  - van Hemert, J. I.
A1  - Baldock, R. A.
ED  - M. Elloumi
ED  - \emph
ED  - et al
KW  - biomedical
KW  - data mining
KW  - DGEMap
KW  - e-Science
AB  - The Edinburgh Mouse Atlas aims to capture in-situ gene expression patterns in a common spatial framework. In this study, we construct a grammar to define spatial regions by combinations of these patterns. Combinations are formed by applying operators to curated gene expression patterns from the atlas, thereby resembling gene interactions in a spatial context. The space of combinations is searched using an evolutionary algorithm with the objective of finding the best match to a given target pattern. We evaluate the method by testing its robustness and the statistical significance of the results it finds.
JF  - Communications in Computer and Information Science
PB  - Springer Verlag
ER  -