The 10-years of the e-Science programme and many earlier years of e-Science have shown the critical importance of digital communication in data-intensive research and in collaboration to bring sufficient expertise to bear on challenges. A review of the 10 years of the e-Science programme shows that the significant positive outcomes are often years after the initial work, even though that led to major breakthroughs and achievements. As the long-tail of researchers are joining in in the use of the new methods and as the wealth of data is growing very rapidly due to many mutually reinforcing positive feedback loops, the need for high-quality networks is ever more pressing. The future JANET6 will be a key element of future data-intensive research just as its predecessors have been key to the many reported successes. The talk concludes with new example applications and some of the challenges for JANET thrown up by our experience of initiating them.