SINAPSE is the “Scottish Imaging Network: A Platform for Scientific Excellence”; it comprises a collaboration of six universities with research imaging facilities. Its objectives are to develop imaging expertise, support multi-centre clinical research in conjunction with the Clinical Research Networks, improve the ability of neuroscientists to collaborate on clinical trials and have a direct impact on patient health. One of the means to achieve these objectives is to provide an e-infrastructure that enables multi-centre clinical research through data sharing. The main objectives of the SINAPSE e-infrastructure project are: