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An Integrative Neuroscience Program Linking Mouse Genes to Cognition and Disease

Figure2.   Schematic representation of Layer 1.

Layer 1 of the Genes to Cognition Program (G2C) is aimed at defining sets of genes encoding "assemblies" or functional sets of genes. The first step is choice of neurobiological problem for which there is considerable molecular data from basic neuroscience experiments, such as learning and memory. Using all available molecular data, with an emphasis on the value of genetic organisms, as well as other data (illustrated in boxes), sets of candidate genes for future human studies are chosen. These genes are used in Layer 2.